Newsletter Archive Online

The San Francisco Tesla Society

presents a free presentation featuring

Roulette Wm. Smith, Ph.D.

"Evolution & Long-Term Memories in Living Systems
Using molecular biology to resolve three great debates …
Lamarck versus Darwin, Nature versus Nurture, and the Central Dogma"

Sunday, February 12, 2006  1 - 5 p.m. at

Tommy's Joynt
Rear Meeting Room
1101 Geary Blvd. (at Van Ness Avenue)
San Francisco, California

It is extremely rare that seminal scientific discoveries lead to profound changes in established and well-heeled beliefs. In the life sciences, and particularly molecular biology, Barbara McClintock’s discovery of transposons possibly qualifies as such a seminal event because her work demonstrated unanticipated dynamicity in DNA. Susumu Tonegawa’s discovery of rearrangements in immunoglobulin genes refuted the "one-gene – one protein" hypothesis. It also provided the first clues to interdependently evolving systems because rearranged genes were not communicated to the germ-line. Two February 2001 reports (i.e., that two independent Human Genome Projects [HGPs] found that the human "proteome" constitutes as little as 1.2% of the human genome and it contains as few as 20,000 genes) now presage a major revolution in scholarly inquiry – in the life sciences (and especially genetics), logic and the philosophy of sciences, curriculum and instruction, and, social and clinical sciences.

These HGPs provided the first solid, albeit circumstantial, support for Smith’s 1979 hypothesis that DNA must be the repository for long-term memories [LTM] – especially in brain and the immune system. Thus, the HGPs, when coupled with Smith’s hypothesis, now provide a compelling basis for nine findings:

•     Three corollaries to these findings are:

using Immanuel Kant’s notions of the a priori and a posteriori, DNA changes in neurons represent a priori events and axon-dendrite development and connectivity represent a  posteriori events;

"preliophic" (i.e., protonic-electronic-ionic-photonic) devices and processes invented by Smith (patents pending) emulate cellular micro-geography and both (i.e., direct and inverse) molecular information pathways; and,

multivalent killed vaccines against relatively uncommon pathogens can provide efficacious vaccines against AIDS.

In addition to these nine findings, evolutionary perspectives on several clinical, methodological, and ethnomethodological issues and their underpinnings are instructive. Clinical issues include roles of slow viruses in dementia and immune dysfunction, the effects of transmissible negativism and other "psychoviruses" on cognition and behavior (and especially aberrant commonsense), the biogenesis of terrorism and post-traumatic stress disorders, autism and "temporary autism" (hypothesized by Malcolm Gladwell in Blink), and, vaccine development for HIV/AIDS.

Methodological issues include applications of epidemiology in studies of non-genetic transmissions and the spread of HIV/AIDS, noninvasive imaging of nucleic acid changes in brain, and, statistical and economic challenges associated with "knowing when and how to ‘stop’" (as in addictions, experiments, and timeseries events). Ethnomethodological issues include disambiguating causality and consequences (especially in the context of revising the Henle-Koch postulates for complex microbes such as HIV and EBV), epigenetics, gedanken studies, and, intriguingly, what may be the meaning of evolution. Regarding the latter, it is said that history is written by winners, and rarely by losers. Studies of evolution fundamentally require histories and understanding of losers and extinctions.

Roulette Wm. Smith is the Director of the Institute for Postgraduate Interdisciplinary Studies in Palo Alto. He also is an adjunct professor at the Institute of Transpersonal Psychology in Palo Alto. He has published extensively on HIV and AIDS, prions, commonsense, transmissible negativism, and mathematical modeling in the social sciences. Smith earned his Ph.D. at Stanford in 1973. He also attended medical school at the University of California, San Francisco from 1976 o 1980.

PDF Version of our February - April 2006 Newsletter


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